CD86 (B7-2) on Human B Cells

Regulation of B7-2 (CD86) Expression in B Cells

B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells.

The costimulatory molecule B7-2 (CD86) is expressed on the surface of APCs, including B cells. Considering the importance of B7-2 in regulating both T and B cell function, it may be important to understand the regulatory mechanisms governing its expression. We report in this study that stimulation of the B cell receptor (BCR) and/or a neurotransmitter receptor, the beta(2)-adrenergic receptor (...

CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells.

Immunoglobulin (Ig) E production by B cells requires two primary signals provided by T cells, interleukin (IL)-4 or IL-13 and CD40 ligand (CD40L). In addition, costimulatory signals, such as CD23-CD21 interaction, contribute further ensuring a selective control over this production. Recently, CD28, expressed on T cells, has been reported to be involved in this process. The CD28 ligands, CD80 (B...

association of co-stimulatory human b-lymphocyte antigen b7-2 (cd86) gene polymorphism with colorectal cancer risk

aim : this study investigated the role of cd86 +237 g/c polymorphism in intensifying the risk of crc development. background : colorectal cancer (crc) is a multi-factorial diseases. genetic background could affect the susceptibility of individuals to crc development. cd86 is a co-stimulatory factor on antigen-presenting cells that plays key roles in several cancer related mechanisms such as aut...

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells

Dendritic cells comprise a system of highly efficient antigen-presenting cells involved in the initiation of T cell responses. Herein, we investigated the role of the CD28 pathway during alloreactive T cell proliferation induced by dendritic-Langerhans cells (D-Lc) generated by culturing human cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating factor and tumor necr...